The article describes the issues of preparing future primary school teachers for new professional competencies. The article describes the need to prepare future teachers for the formation and consolidation of skills of the XXI century in the system of 4K. The individual content of skills and features of training in accordance with the model of 4K. According to the updated educational program, the reasons and expected results of the introduction of the natural science subject in the primary level are presented. The possibility of a natural science subject in primary classes in the formation of a wide range of skills is shown. Science lessons have a great potential for mastering the skills of group 4K, based on the basis of integration education. In the organization of the course "methods of teaching natural science in primary classes" students are offered the most effective forms of innovative teaching methods: "Fishbone", "smart 6 hats", "Zigzak", "SCAMPER", which have been tested. Each of them is characterized and confirmed by methods that allow to improve the skills of the group of 4K, necessary for the professional activities of future teachers.